Yes, at least according to J.D. Vertrees. His book Japanese Maples goes into it in great depth. Here is a paragraph from it where he touches on the subject.
“The native Japanese Maple has the tendency to produce great variations within the species. By selection and cross-pollination over 250 cultivars have been developed. Plants to fit every need in landscaping can be found, from the extremely dwarf forms with minute leaves to the bold upright types with large leaves. There are variations of color in foliage in Spring growth which are not found in other types of trees. Fall coloration among these cultivars becomes a second period of color explosion. There are variations of leaf shape from tiny, crinkled, strap-like, and lace-like to the bold, broad, large leaves of ‘Osakazuki’. As time has passed these beautiful ornamental plants have found their way around the world in horticulture. Discerning plantsmen in many countries have recognized the beauty available in the use of these plants. They fit well with other genera as companion plants or make outstanding specimen plants.”