The short answer is yes. The longer answer is, when you defoliate a tree you're necessarily restricting the tendency toward the lankier, vegetative growth that can thicken a branch quickly. This is why we often use sacrifice branches directly on the branches we want to thicken, particularly if the tree is farther along in its design and we need to correct an imbalance among the branches.
The process of branch thickening is straightforward. As a new branch extends it swells due to the need to conduct water and nutrients to the developing leaves and return sugars and other compounds to the rest of the tree below its position. Each new flush of growth on the branch adds thickness, the amount depending on how long you let it grow. So for trees that are fully designed and get defoliated each year, you don't really see the thickening that you would if the growth were left to go wild, but the process is still occurring.
Hope this helps. And thanks for the kind words.
Zach