The main goal is antagonizing those gibberellins... if only there was a natural way to do it like there is with Auxin! And maybe there is! We need some experimentation!
As with most hormones, an overdose will render the plant insensitive to it.
Google search for 'The round-up ready coca' or something like that. The US spraying herbicides all over Colombia has left the Colombians with herbicide-proof coca plants.
As someone who has been fooling around with Colombian coca plants, I can safely say that they do not at all behave the same as samples collected from far away plant libraries. They do not respond to any known auxin - and I've tried over 400 different recipes - while the ones that were stored elsewhere can be multiplied easily through cuttings. The worst part is that it's genetically transferred, meaning I can't cross out this resistance to auxins.
In practical terms, this means that if I want to keep these relatively short-lived plants for the rest of my life, I have to produce seeds. Meaning I have to get an artists pencil and manually pollinate every single flower hoping for success.
They have a 1 in 200 pollination rate and flowers last about a day or two, so I can effectively produce 10 seeds a year if I'm lucky.